_Congenital hypothyroidism (crenitism)
_Drug-induced hypothyroidism (e.g. by
lithium, amiodarone, interferon-alfa
and tyrosine kinase inhibitors such as
imatinib and erlotinib)
_Following radio-iodine therapy
_Following pituitary surgery or damage
_Auto-immune thyroiditis (Hashimoto disease)
_Neonate:Tabs 10µg/kg/day (increased at a dose of 5µg/kg/day fortnightly to max. dose 25-37.5µg/day).
_Children one month to 12yrs: Tabs 5-10µg/kg/day (increased at a dose of 25µg/kg /day2-4 weekly.
_Children 12-18yrs: Tabs 50-100µg/day (increased at a dose of 50µg/day 3-4 weekly to a maintenance dose of 100-200µg/day