Leukoplakia

Notes

## Basic introduction

  • This is a firmly attached white patch on a mucous membrane that is associated with an increased risk of cancer
  • Risk factors:
  • Tobacco
  • Alcohol
  • Betel nuts

## Statistics

  • The proportion of localized leukoplakia that develops into squamous cell carcinoma is 3-15%
  • The proportion of proliferative leukoplakia that develops into squamous cell carcinoma is 70-100%
Symptoms
  • Firmly attached white patch on a mucous membrane
  • Red patches
Diagnosis
  • Clinical review
  • Tissue biopsy
  • It is not diagnostic
  • It shows increased keratin build up with or without abnormal cells
Differential
  • Candidiasis
  • Oral hairy leukoplakia
  • Lichen planus
  • Condyloma acuminatum
  • Darier's disease
  • Hereditary benign intraepithelial dyskeratosis
  • White sponge nevus
Prevention
  • Cessation of smoking
  • Reduced alcohol intake
Reference

1. James, W. D., & Lupton, G. P. (1988). Acquired dyskeratotic leukoplakia. Archives of dermatology, 124(1), 117-120.

Management
  • None is known
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