_Oocysts in cat’s feces
_Materials contaminated with cat’s feces are ingested by intermediate hosts such as domentic animals and rodents
_Oocysts develop into tachyzoites
_Tachyzoites spread throughout the body and form tissue cysts in neural and muscle tissue
_Humans are infected by ingesting undercooked meat containing tissue cysts, materials contaminated with cat’s feces, by blood transfusion and transplacental transmission from mother to fetus occurs.
_Formation of tissue cysts in human mainly in skeletal muscle, myocardium, the brain, and the eyes
_Reactivation of the cysts (though rare) in the immunocompromised host
_Tabs Pyrimethamine 200mg in 2 doses on day 1, then 25-100mg for 6-8 wks.
_Tabs Sulphadiazine 75mg /kg (max.4gm) day 1, then 100mg/kg/day (max. 6gm) in 2 divided doses for 6-8 wks.
_Caps Clindamycin 600-1200mg TID with any of the two drugs above for 6-8 wks.