Acrokeratosis verruciformis


## Basic introduction

  • An autosomal dominant genodermatosis that is characterized by multiple planar wart-like lesions, mainly observed on the dorsum of the hands and feet
  • It is also known as “Acrokeratosis verruciformis of Hopf” or AVH
  • It is associated with defects in the ATP2A2 gene[a]

## Statistics

  • This is a rare hereditary disease
  • It has no gender preference.
  • Symptoms and sign are present from birth or early childhood though, rarely, it can arise in adult life
  • Multiple plantar wart-like lesions
  • Lesions mainly observed on the dorsum of the hands and feet
  • Verrucous, flat papules resembling warts along with palmoplantar punctate keratoses and pits (mainly on the knees, elbows and forearms)
  • Pits on the palms of the hands and soles of the feet
  • Nail dystrophy
  • Pearly white nails, or nails with longitudinal ridges and nicks in the free edge
  • Clinical review
  • Darier's disease
  • Epidermodysplasia verruciformis
  • Plane warts
  • Seborrheic keratoses
  • Stucco keratoses
  • None is known

a. Gupta, A., Sharma, Y. K., Vellarikkal, S. K., Jayarajan, R., Dixit, V., Verma, A., ... & Scaria, V. (2016). Whole-exome sequencing solves diagnostic dilemma in a rare case of sporadic acrokeratosis verruciformis. Journal of the European Academy of Dermatology and Venereology: JEADV, 30(4), 695-697.

b. Hopf, G. (1931). Akrokeratosis verruciformis. Dermatology, 60(4), 227-250.

c. Andrade, T. C. P. C. D., Silva, G. V. D., Silva, T. M. P., Pinto, A. C. V. D., Nunes, A. J. F., & Martelli, A. C. C. (2016). Acrokeratosis verruciformis of Hopf-Case report. Anais brasileiros de dermatologia, 91(5), 639-641.

  • There is no definite treatment
  • Cosmetic treatment may include:
  • Superficial ablation
  • Retinoic acid
  • Cryotherapy
  • Laser radiation are sometimes useful
Drug Index 2.0 is here
Our new update features a more powerful search feature and easier login. Having any issues? Contact us today. Contact Us