Acropustulosis of infancy

Notes

## Basic introduction

  • This is also known as infantile acropustulosis
  • It is a recurrent, pruritic, vesicopustular eruption of the palms and the soles that affect children up to the age of 2-3 years
  • It is sometimes associated with scabies[a][b]

## Statistics

  • It is generally a rare disease
  • It shows equal gender dominance
Symptoms
  • Recurrent eruptions of erythematous papules
  • The papules may progress to vesicles and pustules
  • Lesions are located:
  • Mainly on palms and soles
  • Dorsum aspect of hands and feet, limbs, trunk, face and scalp to a lesser extent)
  • Pruritus
Diagnosis
  • Clinical review
Differential
  • Candidiasis
  • Congenital syphilis
  • Eczema dyshidrotic
  • Herpes simplex infection
  • Impetigo
  • Langerhans cell histiocytosis
  • Neonatal toxic erythema
  • Pustular psoriasis
  • Scabies
  • Transient neonatal pustular melanosis
Prevention
  • None is currently known
Reference

a. Jarratt, M., & Ramsdell, W. (1979). Infantile acropustulosis. Archives of dermatology, 115(7), 834-836

b. Humeau, S., Bureau, B., Litoux, P., & Stalder, J. F. (1995). Infantile acropustulosis in six immigrant children. Pediatric dermatology, 12(3), 211-214

c. Larralde, M., & Luna, P. (2008). Pustulosis neonatales estériles. Dermatol Pediatr Lat, 6(1), 2-9.

Management
  • The condition is self-limiting with spontaneous resolution being observed around the age of 3
  • High-potency topical corticosteroids
  • Dapsone (reserved for recalcitrant cases)
  • Antipruritics
  • Pramoxine
  • Topical antibiotics are added in cases of secondary infections
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