- Partial or radical nephrectomy (especially in stage 1- III)
- Metastectomy (especially with metastatic growth in the lymph nodes and the lungs) where the tumor has metastasized and the removal of the mass will give some relief.
- Traditional adjuvant therapy has not been successful with RCC but the following treatment has been promising:
_Interferon-alpha in combination with bevacizumab (anti-vascular endothelial growth factor, anti-VEGF)
_Interleukin-2 (administered in the ICU)
_Tyrosine Kinase Inhibitors (TKIs) such as sunitinib and sorafenib.
_Mechanistic target of rapamycin (mTOR) protein kinases such as sirolimus, everolimus and temsirolimus