- Surgical removal: either by tangential scissor excision, tangential shave excision, curettage, or electrosurgery
- Podophyllin 25% in tincture of benzoin: apply on the wart, protect the normal skin, wash after 1-4hrs, repeat after 1-2wks upto 4 applications and if not effective use other medications. This mainly provider-administered medication.
- Podophyllotoxin 5%: Apply BD x 3/7, repeat the cycle after 4 days rest [up to 4 cycles]. This can be patient-administered medication
- 5-Fluorouracil cream: Applied OD or BD.
- Silver nitrate pencil 95%: Apply OD x 3/7, by dipping the tip in a drop of water (protecting healthy skin around the area to be treated with a thin layer of petroleum jelly) and rolling the tip on the area to be treated.
- Cryotherapy (with liquid nitrogen or nitrous oxide using cotton tip applicator or cryoprobe by experts only). Safe in pregnancy.
- Trichloroacetic acid (80-90%): Applied and allowed to dry once per wk. This mainly provider-administered medication
- Imiquimod cream 5%: Applied at bed-time 3 times /wk for upto 16 wks and wash the area 6-10hrs after application. This can be patient-administered medication.
- Sinecatechines (a green-tea extract) 15% Oint: Applied TID for up to 16 wks without washing. This can be patient-administered medication.
- Podophyllotoxin is standardized and stable, whereas podophyllin has a variable composition.
- To examine and treat the sex partners too.
Circumcision may prevent recurrence in men who are not circumcised.