100mg TID for adults and 1.5 mg/kg TID for children.
Mode of action
Brands containing this Ingredient
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Mode of Action
It is rapidly converted in the body to thiorphan which is a potent enkephalin- ase inhibitor. Enkephalins are endogenous opioid peptides secreted by myenteric and sub mucosal neurons in the digestive tract. The enkephalins activate the δ opioid receptor, inhibiting the secretion of Cl– and fluids thus reducing the loss of fluids and electrolytes during diarrhea.
Itching; depression in children in children below 2 years; abdominal distension