Hypertension,initially 10mg daily, increased if necessary after 4 weeks; usual dose range 10–40mg [doses over 40mg not shown to increase efficacy]. Heart failure [adjunct], initially 10mg once daily under close medical supervision, increased gradually to 40mg once daily if tolerated.
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Inhibition of the conversion of angiotensin I to angiotensin II.
Severe CCF, impaired renal function, lactation, aortic stenosis, NSAIDs, monitor serum lithium levels, first dose may cause hypotension especially in dehydrated cases, low sodium serum levels, diuretic treated cases, monitor renal function, may potentiate hypoglyceamic effects of insulin or oral hypoglycaemic agents, haematological monitoring. Avoid potassium sparing diuretics or potassium supplements.
Pregnancy, history of angioneurotic oedema with previous ACE inhibitors, hypersensitivity, renal vascular disease, porphyria.