Prophylaxis and treatment of malaria resistant to other drugs.
20mg/kg (of the base) STAT or 10mg/kg STAT, then 10mg/kg after 6-8hrs. Prophylaxis: 1 tab weekly from 1 week before travelling and for at least 6 weeks after travelling.
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Thought to inhibit heme poly- merase activity resulting in accumulation of free heme, which is toxic to the parasites.
Increased risk of convulsions in epileptics, contraceptives during prophylaxis and for 3 months following last dose period, perform liver function tests, cardiac and opthalmological functions, cardiac conduction disturbances, unexplained depression or anxiety.
Pregnancy, lactation, history of psychiatric disorders when quinine has been used. Impaired hepatic and renal functions, children with BM of less than 5kg.
Anorexia, nausea and vomiting, abdominal pain, diarrhoea, headache, bradycardia, neuropsychiatric disorders, rashes, pruritis, paraesthesia, general weakness, hair loss, fever, chills, muscle weakness and cramps. Erythema, myalgia, arthralgia.