Inflammatory and degenerative forms of rheumatism, pain following dental surgery, dysmenorrhoea, gout, painful muscular and skeletal conditions.
For Adults and Children older than 12 yrs : 1 tablet BD to TID
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It acetylates prostaglandin endoperoxide synthase and irreversibly inhibits its cyclo-oxygenase [COX] activity. This enzyme catalyzes the conversion of arachidonic acid to PGH2. It has two isoforms: COX-1 and COX-2. Acetylation of platelet cyclo-oxygenase prevents the synthesis of thromboxane A2 [a potent vasoconstrictor and inducer of platelet aggregation].
Hepatic and renal impairment, elderly, diabetes, diuretic therapy, and abscess.
Peptic ulcer, asthma, pregnancy, children under 2 years, and hypersensitivity to diclofenac.
Hypersensitivity, active peptic ulcer or GI bleeding, Pancreatitis,