1-2 tablets at onset followed by additional 1-2 tablets at intervals of at 30mins [max. 4 tabs in 24 hours]. Not to be repeated at intervals of less than 4 days [max. 8 tabs weekly].
Mode of action
Brands containing this Ingredient
Drug Index 2.0 is hereOur new update features a more powerful search feature and easier login.
issues? Contact us
today. Contact Us
Mode of Action
Ergotamine interacts with sever-
al neurotransmitter receptors, including alpha-
adrenergic, serotonergic and dopaminergic receptors. It directly stimulates vascular smooth mus-
cle causing constriction of both arteries and veins
and depresses vasomotor centers in the brain.
More specifically, it is thought that agonist activity at the 5-HT1D receptor subtype provides relief
of acute headache, whereas antagonist activity at
the 5-HT receptor subtype provides headache 2
prophylaxis. Caffeine is thought to act by increasing both the rate and extent of absorption of ergotamine.
Repeated high doses may cause ergotism with gangrene, confusion, nausea, vomiting, headache and pleural and peritoneal fibrosis.