Adult: 120mg in the first day, then 60mg OD x 4/7 or 6/7. 11-15yrs: 90mg stat then 45mg OD 4/7 or 6/7, 7-10yrs: 60mg stat, then 30mg OD 4/7 or 6/7 [max. 240mg], 4-6yrs: 40mg stat, then 20mg OD x 4/7 or 6/7 [max. 160mg], 1- 3yrs: 30mg stat, then 15mg OD x 4/7 or 6/7 [max. 120mg], less than 1yr: 20mg stat, then 10mg OD x 4/7 or 6/7.
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Artemisinin derivatives are concentrated in the parasitized erythrocytes and it is believed that iron from ingested haemoglobin of the parasite‘s victim reduces ―Endoperoxide Bridge‖ releasing a highly reactive free radical iron [IV] oxo species that rips apart the parasitic cells.