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Monitoring of aminotranferases, bilirubin level, cholesterol and triglycerides, on bi-monthly basis; increased risk of nephrolithiasis in case of dehydration; reduce dose in case of marked liver impairment; blood concentration is reduced in the 3rd trimester of pregnancy.
Acute porphyria, hypersensitivity reactions, alprazolam, alfuzosin, amiodarone, rifampicin and sildenafil.
Common side effect is nephrolithiasis (kidney stones) which is more likely in children