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Very useful in prevention of vertical transmission of HIV in the late pregnancy.
It is rarely affected by the status of renal functions hence there may not be any need of changing the dosage in case of renal impairement unless the creatinine clearance is below 20mlL/minute; paradoxically probability of hepatoxicity. increases with the increase of CD4 counts, with more pronounced effect in women. Rifampicin reduces its plasma concentration. Known to cause serious dermatological reactions in children. The incidence for rash is reduced if introduced at a low dose and dose increased after 14 days.
Severe hepatic disorders (with AST or ALT levels of more than 5 times of the normal levels).