300mg depending creatinine clearance (CCr). For CCr 30-49ml/min: 300mg after every 48hrs. For CCr 10-29ml/min: 300mg twice a week. For CCr less than 10ml/min do not use tenofovir. Taken with meal
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A reverse transcriptase inhibitor.
Level of didanosine is raised when used with tenofovir hence it should be given at least 2hr before or 1hr after taking ddI. Tenofovir level is raised by antivirals acyclovir, ganciclovir and valaganciclovir.
Lactic acidosis; allergy.
Headache; nausea, flatulence, anorexia, diarrhea, abdominal; renal dysfunction and change in fat distribution.