HIV in adults and children with progressive or advance immunodeficiency. (T-helper cell counts of less than 500/mm3). Used in combination with other ARVs.
Asymptomatic disease - initially 500mg to be increased as the disease progresses to 1.5g daily. Symptomatic disease 200mg every 4hrs. If tolerance is poor - 100mg every six hours. Children over 3months -180mg/m2 every 6hrs. I.V inf. - 2.5mg/kg every 4 hrs (for less than 2 weeks.
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Hepatic and renal impairment, 1st trimester of pregnancy, avoid in lactation, monitor haematological parameters.