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Mode of Action
Binds to the ribosomal 50S subunit in domain V of the 23S rRNA
Use of antibiotics may promote overgrowth of non-susceptible organisms.
Concurrent use with SSRIs, 5HT1 agonists, tricyclic antidepressants, sym- pathomimetics, dopaminergics, buspirone, pethidine and some opioid analgesics. Hypersensi-
tivity to the drug or other product components.
╬It has acceptable activity against important gram-positive pathogens such as MRSA, penicillin-resistant pneumococci, macrolide-resistant streptococci, and vancomycin-resistant enterococci.
╬It is 100% bioavailable, so it can be given in equal doses orally or parenterally.