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Protease inhibitors [PI] inhibits HIV proteases, preventing viral maturation and replication
Monitoring of aminotranferases, bilirubin level, cholesterol and triglycerides, on bi-monthly basis; increased risk of nephrolithiasis in case of dehydration; reduce dose in case of marked liver impairment; blood concentration is reduced in the 3rd trimester of pregnancy.
Acute porphyria, hypersensi-tivity reactions, alprazolam, alfuzosin, amioda-rone, rifampicin and sildenafil.
Common side effect is nephrolithia-sis [kidney stones] which is more likely in chil-dren; unconjugated hyperbilirubinaemia; malaise; flank pain; back pain; abdominal pain; alopecia; ingrown toe nails; dried cracked skin [‗retinoid syndrome‘]; vasculitis; oedema; haemolytic anaemia and hepatitis.