Chronic iron overload due to blood transfusions in patients 2 years and above.
Initially 20mg/kg daily. Depending on the ferritin trend the dose is adjusted every 3 to 6 months done on steps of 5 or 10 mg/kg [max.40 mg/kg]
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Brands containing this Ingredient
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A chelating agent with high affinity for binding with iron.
Renal impairment: It has potential to cause renal failure.
Hepatic impairment: It has potential to cause hepatic failure.
Special information: The first orally active iron chelating drug.
Allergy to deferasirox or any other component of the formulation; CrCl less than 40 mL/min; advanced malignancies.
Abdominal pain; nausea; vomiting; diarrhea; cholelithiasis; duodenal ulcers; gastric ulcer, gastritis; GI hemorrhage; rash; proteinuria and cytopenias.
Anticoagulants such as warfarin [additive effects]; drugs with the potential of causing GIT irritation such as NSAIDS, bisphosphonates and corticosteroids [additive effects]; steroid-based contraceptives [their absorption is reduced]; phenytoin, rifampin and other potent UDP-glucuronosyltransferase [UGT] inducers, cholestyramine [efficacy of deferasirox is reduced], paclitaxel [increased plasma concentrations].