For all types of acute leukemias; chronic myeloid leukemia; AIDS-related Kaposi's sarcoma; disseminated neuroblastoma.
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It is thought to inhibit DNA- dependent RNA synthesis by forming a complex with DNA through intercalation with guanine residues and impairing the template activity of DNA. It also has some immunosuppressive and hypocalcaemic activities.
Only physicians experienced in cancer chemotherapy should use it; increased incidence of infections; severe myelosuppression with resulting infection or bleeding may occur; cardiac function should be monitored regularly.
Myelosuppression [sometimes severe]; cardiac toxicity and congestive heart failure; triad of back pain; flushing; and chest tightness; increased appetite; dysphagia; GI haemorrhage; gastritis; stomatitis; nausea and vomiting; gingival bleeding; hemorrhoids; melena; diarrhea; abdominal pain; anorexia; and constipation; dry mouth; taste perversion; thirst; hiccups; or tooth caries; neuropathy; amnesia; anxiety; ataxia; confusion; emotional lability; hallucination; hyperkinesias; hypertonia; tremor; somnolence; seizures; alopecia; pigmentation of fingernails and toenails; severe local tissue damage in extravasation; fever; myalgia; hypocalcaemia; hypersensitivity reactions.
Consult specialist literature for further infor- mation.
It is an anthracycline glycoside antibiotic produced by Streptomyces coeruleorubidus. It is structurally related to doxorubicin, differing with it by bearing an acetyl group instead of a hydroxyacetyl group in the 8-position.