Severe psoriasis, palmo-plantar pustular psoriasis, congenital ichthyosis and Darier‘s disease
Adults: Initial daily dose: - 25mg or 30mg for 2-4 wks then 25-50mg for a further 6-8 wks. [Max. dose: 75mg/day]. Children: 0.5mg/kg daily [up to 1mg/kg daily]
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Pregnancy and those likely to be pregnant during or within 2 years of the cessation of treatment; hepatic or renal impairment; abnormally elevated blood lipid values; antibiotics such as tetracyclines; methotrexate; breast feeding
Highly teratogenic;dry skin; scaling, erythema; thinning of the skin; pruritus; dermatitis; sticky skin; epidermal and nail fragility; hair thinning and frank alopecia; granulomatous lesions; dry mucous membrane; corneal ulceration; headache; myalgia; arthralgia; blurred vision; vulvo-vaginal candidiasis.