Hypersensitivity reactions to any xanthine, peptic ulcers, and epilepsy
Doxofylline (7-(1,3-dioxalan-2-ylmethyl) theophylline) has similar efficacy with theophylline but has fewer side effects.
Plasma monitoring is required only in patients with hepatic insufficiency and intolerance to xanthine drugs since it produces stable serum concentrations.
It does not antagonize calcium channels as it does not interfere with the influx of calcium into the cells
It does not affect sleep rhythm, gastric secretions, heart rate, and rhythm. and CNS functioning.