Treatment and prophylaxis of hypokalaemia; metabolic alkalosis; in chronic digitalis intoxication; hypokalaemic familial periodic paralysis; those on potassium-depleting drugs like thiazides and loop diuretics; hepatic cirrhosis with ascites; in chronic and secondary hyperaldosteronism; chronic diarrhoea; chronic laxative use; prolonged vomiting; long-term corticosteroid therapy; potassium losing nephrop-athy; Bartter's syndrome.
HYPOKALEMIA, MILD TO MODERATE: Orally: 40-100 mEq daily in divided doses (Max. single dose: 25 mEq to reduce GI discomfort). SEVERE HYPOKALEMIA: Orally 40 mEq TID to QID OR alternatively 20 mEq PO BID to TID with IV potassium administration. HYPOKALEMIA PROPHYLAXIS:
Orally 10-20 mEq BID. IV intermittent infusions; less than or equal to 10 mEq/hr to repeated as directed by lab values and ECG monitoring. DOSING DIRECTED BY SERUM POTASSIUM LEVELS: For potassium levels of 2.5-3.5 mEq/L administer infusion at a maximum rate of 10 mEq/hr; for 40 mEq/L do not to administer more than 200 mEq dose in 24hr.
Mode of action
Brands containing this Ingredient
10% w/v; amp
Potassium chloride, Kilitch
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It is the main intracellular cation. Na+K+ATPase actively pumps sodium out and potassium into cells to maintain these concentration gradients. These potassium concentration gradients are necessary for the conduction of nerve impulses it the heart, brain, and skeletal muscle, and for the maintenance of normal renal function and acid-base balance. High intracellular potassium concentrations are necessary for nu-merous cellular metabolic processes.
The loss of fluid accompanied by the use of potassium supplements can cause renal toxicity; conditions that can cause delay absorption of potassium can cause or worsen GIT irritation; conditions predisposing to hyperkalemia, such as acute metabolic acidosis, adrenal insufficiency, acute dehydration, and uncontrolled diabetes mellitus.
Hyperkalaemia; irritation of the GIT; diarrhea; nausea; vomiting; hypersensitivity to potassium