Hypertension: starting dose: 25mg daily. Stable, chronic heart failure: starting dose: 25 to 50mg/day (Max.100 to 200mg/day)
Mode of action
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Mode of Action
It inhibits Na+ reabsorption in the cortical segment of the distal tubule and to a lesser degree K+ and Mg2+. Its vascular effect is manifested by an increase in arterial compliance and a decrease in total peripheral and arteriolar resistance, without altering heart rate.
Allergy to any component of formulation or other derivative of sulphonamide, anuria, severe hepatic failure, severe renal failure, pregnancy.