Inhibition/suppression of physiological lactation; treatment of hyperprolactinaemic disorders.
Inhibition/suppression of physiological lacta-tion: 1mg STAT (immediately post-partum) or 0.25mg BD x 2/7. Treatment of hyperprolacti-naemic disorders: 0.25 mg to 2 mg per week.
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It is an ergot derivative with potent D2-dopamine receptor agonist activity. The dopaminergic neurons in the tuberoinfundibular process modulate the secretion of prolactin from the anterior pituitary by secreting a prolactin inhibitory factor [thought to be dopamine]. It significantly reduces plasma levels of prolactin in patients with physiologically elevated prolactin as well as in patients with hyperprolactinemia.
It causes drowsiness and postural hypotension. Impulse control and hepatic disorders.
hepatic insufficiency; toxaemia of pregnancy, puerperal psychosis, patient on anti-psychotic medications, and allergy to any component of the formulation.
Allergic reactions, headache, dizziness, valvulopathy, pericarditis and pericardial effusion, fatigue, hypotension, constipation, vomiting, somnolence and depression.