Induction of ovulation and pregnancy [in anovulatory infertile patients in whom the cause of infertility is functional and not due to primary ovarian failure]; development of multiple follicles in ovulatory patients participating in an Assisted Reproductive Technology [ART] pro-gram.
Assisted Reproductive Technologies [ART]: A starting dose of 150 to 225 IU of follitropin Beta for at least the first four days of treatment after which the dose is adjusted based on the ovarian response [maximum dose is 600 IU]. When a sufficient number of follicles of adequate size are present, the final maturation of the follicles is induced by administering hCG at a dose of 5000 IU to 10,000 IU after which the Oocyte retrieval is performed 34 - 36 later [the administration of hCG must be withheld in cases where the ovaries are abnormally enlarged on the last day of treatment in order to reduce the chance of developing OHSS. Ovulation Indication suction A step-wise gradually increasing dosing scheme can be used. Starting dose of 75 IU is given for up to 14 days. The dose is then increased by 37.5 IU at weekly intervals until follicular growth and/or serum estradiol levels indicate an adequate response [max. dose - 300 IU]. The patient is treated until ultrasonic visualizations and/or serum estradiol determinations indicate pre-ovulatory conditions equivalent to or greater than those of the normal individual followed by hCG, 5000 IU to 10,000 IU. If the ovaries are abnormally enlarged on the last day of follitropin therapy, hCG must be withheld during this course of treatment; this will reduce the chances of developing OHSS. Seven to ten days post-ovulation. See product literature insert for further