Blood-stage treatment of P. falciparum and P. vivax especially in areas where other ACTs are failing.
Dosage in adults and children: Wt 15 - < 24 kg: 1 tab D OD x 3/7. Wt. 24 - <45 kg 2 tab OD x 3/7. Wt. 45 - < 65kg: 3 tabs OD x 3/7. Wt. ≥ 65 kg 4 tabs OD x 3/7. Dosage in children and infants: BW: 5 - < 8 kg 1 sachet OD x3/7. Wt. 8 - < 15 kg: 2 sachets OD x 3/7. Wt. 15 - < 20 kg 3 sachets OD x 3/7. Wt. 20 - < 25 kg 4 OD x 3/7.
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Artesunate is believed that iron from ingested hemoglobin of the parasite‘s victim reduces ―endoperoxide bridge‖ releasing a highly reactive free radical iron [IV] oxo species that rips apart the parasitic cells. Pyronaridine is a hydroxyanilino-benzonaphthyridine acridine derivative which also includes
amodiaquine-like side chain. Pyronaridine inhibits β-haematin
production and forms complexes with haematin to enhance haematin-induced human blood cell lysis and to inhibit glutathione-dependent degradation of