Diabetes mellitus inadequately controlled by diet or by diet with oral hypoglycaemic agents.
Initially 25mg TID at the start of each main meal. Dosage may be adjusted at 4-8 weeks intervals, first to 50mg TID then, if required, to 100mg TID.
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It inhibits intestinal alpha-glucosidases hence delaying the digestion and absorption of starch and sucrose.
Monitor serum hepatic transaminase in patients on 200mg/day for the first six months; may enhance hypoglycaemic effect of insulin and sulphonylureas. Due to its MOA, hypoglycaemic episodes should be treated with oral glucose not sucrose.
Under 18 years; pregnancy; states that deteriorate due to increased gas formation [e.g. intestinal ulcer and hernia]; breast-feeding; severe renal and hepatic impairment; inflammatory bowel disease; intestinal obstruction; colon ulceration; and history of abdominal surgery.
Flatulence and bowel sounds; diarrhoea; abdominal distension; abdominal pain [less common]; hypersensitivity reactions; jaundice; and hepatitis.
It is an oligosaccharide obtained from fermentation processes of the microorganism Actinoplanes utahensis