Chronic simple (open-angle) glaucoma, secondary glaucoma, acute glaucoma when delay of surgery is desired, lowers intraocular pressure, CCF, drug induced oedema, epilepsy.
0.25 - 1.0g daily orally or 1.V.
Mode of action
Brands containing this Ingredient
Acetazolamide, by Metro
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Mode of Action
It is an enzyme inhibitor that acts specifically on carbonic anhydrase [the enzyme that catalyzes the reversible reaction involving the hydration of carbon dioxide and the dehydration of carbonic acid]. In the eye, its inhibitory action decreases the secretion of aque- ous humor and results in a drop in intraocular pressure. In the kidney inhibition of carbonic anhydrase results in renal loss of HCO3 ion, which carries out sodium, water, and potassium. Inhibition of carbonic anhydrase in CNS appears to retard abnormal, paroxysmal, excessive dis- charge neurons hence its use in CNS conditions like epilepsy.
Blood monitor [as with other sul- phonamides], severe cirrhosis, increasing the dose above the set dose does not increase diuresis, cross-sensitivity with other sulphonamides
Hypersensitivity to sulphonamides, severe renal impairment, hepatic impairment, adrenocortical insufficiency, long-term use in chronic non-congestive angle-closure glaucoma. Severe pulmonary obstruction, low sodium and potassium serum levels
Drowsiness, rashes, crystalluria, bone marrow depression, loss of appetite, flaccid paralysis, glycosuria, hepatic impairment, fever, allergic reaction, impotence.