Uncomplicated and non-ketonic diabetes mellitus (maturity onset type II diabetes)
250mg OD initially[max. 500mg daily] taken after breakfast
Mode of action
Brands containing this Ingredient
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Mode of Action
It acts mainly by directly stimulating the release of insulin from functioning beta cells of pancreatic islet tissue. To achieve this, it inhibits the ATP-potassium channels on the beta cell membrane and potassium efflux. This results in depolarization and calcium influx, calcium-calmodulin binding, kinase activation, and release of insulin-containing granules by exocytosis.
Maintain regular medical monitoring; elderly; barbiturate therapy; dietetic therapy in obese; Addison‘s disease; and disulfiram-like reactions
Diabetes complicated by keto-acidosis; coma; Raynaud‘s disease; pregnancy; gangrene; severe trauma; fever; severe renal/hepatic/thyroid function impairment; juvenile diabetes mellitus; severe and unstable diabetes; severe inflammation.