Endometrial and renal cancer, melanoma, breast cancer
Nephrotoxicity; ototoxicity; neurotoxicity; emesis; increase of urinary excretion of magnesium and calcium to a great extent and that of potassium, zinc, copper, and amino acids to a smaller extent; myelosuppression leading to leukopenia, thrombocytopenia and Coombs' positive hemolytic anaemia; nausea; vomiting; hyperuricemia; optic neuritis; papilledema; cerebral blindness; hypersensitive; cardiac abnormalities; anorexia, elevated SGOT; rash; alopecia.
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Brands containing this Ingredient
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More poorly tolerated overall compared with carboplatin.
Pre-existing renal impairment
in patients who are deeply myelosuppressed
history of allergy to platinum-containing compounds.