Mild to moderate pain especially of visceral origin
By mouth 30-60mg every 4 hours when necessary, to a max. of 240mg daily; children 1- 12 years-3mg/kg daily in divided doses by intramuscular injection, 30-60mg every 4 hours when necessary.
Mode of action
Brands containing this Ingredient
Codeine Phosphate, by Cosmos
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Mode of Action
Asthma; hypotension; hypothyroidism; pregnancy and breast feeding; prostatic hypertrophy; hepatic impairment; renal impairment [as its metabolites tend to accumulate]; children under 1year; 6-10% of caucasians are deficient of CYP2D6 hence codeine is not effective in them.
Acute respiratory depression, risk of paralytic ileus, acute abdomen, acute alcoholic, hypersensitivity to codeine.
Hypotension; bradycardia; respiratory depression; muscle rigidity; itching; arrhythmias and itching.
For codeine to be active, it must be converted first to morphine by CYP2D6.