Initially one mg then 500mcg every two to three hours until the pain is relieved or vomiting or diarrhoea occur or a total dose of 10mg has been administered. The treatment should not be repeated within 3 days. Prevention of attacks during initial treatment with allopurinol or uricosuric drugs: 8-12 hourly.
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Tubulin disruption that leads to subsequent down regulation of multiple inflammatory pathways and modulation of innate immunity.
Periodic blood counts on long term therapy, peptic ulcer or spastic colon.
Allergy against colchine, blood dyscrasia, cardiac disorders, hepatic and renal impairment.
Bone marrow depression resulting in agranulocytosis and thrombocytopaenia, purpura, myopathy, neuritis, loss of hair, reversible azoospermia, vomiting, diarrhoea, allergic reactions.