Respiratory tract infections, otitis media, skin and tissues infections and other infections caused by susceptible micro-organisms.
Usual oral dose of 600mg daily as a single dose or in two divided doses. Twice daily dosing should be used for pneumonia and skin infections. The dose of cefdinir may need to be reduced in patients with renal impairment.Children from 6 months of age may be given 14mg/kg daily as a single dose or in two divided doses [to a maxi- mum daily dose of 600mg].
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Impaired renal functions, penicillin cross sensitivity; there have been reports of reddish stools in patients given cefdinir with iron supplements.
Sensitivity to cephalosporins.
GI disturbances, vaginal moniliasis and vaginitis, allergic reactions, increased prothrombin time, super-infections, hepatic dysfunctions, Stevens-Johnson syndrome, erythema multiforme, fever, CNS effects.
A third generation cephalosporin that is similar to cefixime. In vitro tests show that it is more active than cefixime against S. aureus and E. faecalis but less active against Enterobacteriacea.
Drug interactions: Antacids / food 1 hour before or 2 hours after administration. Renal excretion inhibited by probenecid. Disulfirum-like effect if alcohol is taken within 72 hours after administra- tion. Increased bleeding effect with oral anti- coagulants, increased nephrotoxicity with amino- glycosides.