Prophylaxis of venous thromboembolism in adults after total hip replacement or total knee replacement surgery.
Prophylaxis of venous thromboembolism following total knee replacement surgery,ADULT over 18 years, 110 mg [ELDERLY over 75 years, 75 mg] 1–4 hours after surgery, then 220 mg [ELDERLY over 75 years, 150 mg] once daily for 9 days. Prophylaxis of venous thromboembolism following total hip replacement surgery, ADULT over 18 years, 110 mg [ELDERLY over 75 years, 75 mg] 1–4 hours after surgery, then 220 mg [ELDERLY over 75 years, 150 mg] once daily for 27–34 days.Note: Max. 150mg daily with con- comitant amiodarone or verapamil.
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It is a direct thrombin inhibitor taken orally.
Elderly; bodyweight less than
50 kg; recent surgery; anaesthesia with postopera- tive indwelling epidural catheter [risk of paralysis—give initial dose at least 2 hours after catheter removal and monitor neurological signs]; bacterial endocarditis [increased risk of bleed- ing]; bleeding disorders; active gastrointestinal ulceration; concomitant use of drugs that increase risk of bleeding.