All types of leprosy [of value in dermatitis herpetiform], toxoplasmosis and mycetoma, malarial prophylaxis.
Mode of action
Brands containing this Ingredient
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Mode of Action
Inhibition of bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid [PABA]. [This is a step in the biosynthesis of nucleic acids and proteins required by many bacteria].
Cardiac or pulmonary disease; anaemia [treat severe anaemia before starting]; susceptibility to haemolysis including G6PD deficiency; avoid in acute porphyria; discontinue if severe lepra reactions occur.
Drug interactions: Probenecid reduces its excretion.