Induction of labour; elective abortion [between 12-18 weeks of gestation]; treatment of incomplete abortion; therapeutic abortion [e.g. in cases of intra-uterine fetal death and congenital abnormalities incompatible with life]; injected intra-arterially for use as a vasodilator to assist in angiography
As an abortifacient agent: 40mg [base] intraomniotically [the first 5mg is given at a rate not exceeding 1mg per minute to determine sensitivity and to confirm that the medication is not being administered intravascularly. The remaining 35mg is given over the next 5 minutes. 10-40mg [base] can be given 24hrs after the initial dose if the abortion process is not established or completed as long as the membranes are still intact. Induction of labor: IV infusion 2.5 mcg per minute [when required, the dose can be doubled hourly to maximum of 20 mcg per minute to maximum total dose of 1 - 4 mg].
See product literature for further details.
Mode of action
Brands containing this Ingredient
Drug Index 2.0 is hereOur new update features a more powerful search feature and easier login.
issues? Contact us
today. Contact Us
Mode of Action
It stimulates myometrial contractions in the gravid uterus. It also facilitates cervical dilatation and softening. In addition, it stimulates the smooth muscle of the gastrointestinal tract, arterioles, and bronchioles.
Pregnancy termination can fail; history of anemia; hypertension or hypotension; cardiovascular disease; diabetes mellitus; renal disease; pre-eclampsia; uterine fibroids; cervical stenosis; uterine surgery; epilepsy; glaucoma; multiparity.
Allergic reaction to dinoprost or related drugs; history of asthma; active pulmonary disease; significant cephalopelvic disproportion; malpresentation of fetus; active pelvic inflammatory disease; ruptured membranes.
Anaphylaxis; bronchoconstriction; burning eyes; endometritis; second-degree heart block; urinary retention; bradycardia; adynamic ileus; peripheral vasoconstriction; tachycardia; and increased uterine bleeding or pain; severe and continuing abdominal or stomach pain; double vision; dysuria; hematuria; paresthesias; leg, back, chest, or shoulder pain.
Drug Interactions: Although its combination with oxytocics is used for therapeutic advantage adequate care should be taken as this may result in uterine hypertonus that can lead to uterine rupture or cervical laceration.