Induction of labour; elective abor- tion [between 12-18 wks of gestation]; treatment of incomplete abortion; therapeutic abortion [e.g. in cases of intra-uterine fetal death and congenital abnormalities incompatible with life]; cervical ripening; treatment of postpartum haemorrhage; treatment of benign hydatidiform mole
Vaginally. Insert high into posterior fornix 3mg followed by another 3mg 6-8hrs later incase the labour is not established [max. 6mg]
Mode of action
Brands containing this Ingredient
Glandin -E2 Vaginal Tablets
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Mode of Action
It stimulates myometrial con- tractions in the gravid uterus. It also facilitates cervical dilatation and softening. In addition, it stimulates the smooth muscle of the gastrointesti- nal tract, arterioles, and bronchioles. For cervical ripening, it softens the cervix and facilitates cervical dilation and effacement. It also stimu- lates collagenase secretion hence reducing the collagen network within the cervix.
Pregnancy termination can fail; history of anaemia; hypertension or hypotension; cardiovascular disease; diabetes mellitus; renal disease; pre-eclampsia; uterine fibroids; cervical stenosis; uterine surgery; epilepsy; glaucoma; multiparity.
Allergic reaction to dinoprostone or related drugs; history of asthma; active pulmonary disease; significant cephalopelvic disproportion; malpresentation of fetus; active pelvic inflammatory disease; ruptured mem- branes.
Anaphylaxis; bronchoconstriction; burning eyes; endometritis; second-degree heart block; urinary retention; bradycardia; adynamic ileus; peripheral vasoconstriction; tachycardia; and increased uterine bleeding or pain; severe and continuing abdominal or stomach pain; double vision; dysuria; hematuria; paresthesias; leg, back, chest, or shoulder pain.
Drug interactions: Although its combination with oxytocics is used for therapeutic advantage adequate care should be taken as this may result in uterine hypertonus that can lead to uterine rupture or cervical laceration.