Organic and idiopathic venous diseases such as chronic venous insufficiency (CVI) of the lower limbs with symptoms that include heavy legs
CVI: 2 OD [morning or evening] or 1BD HD: Acute episode: 6 tabs daily for 4 days, followed by 4 tabs daily for 3 days. Prevention of recurrence: 2 tabs daily for a minimum of 3 months.
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Vascular protector and venotonic that acts on the return vascular system reducing venous distensibility and venous stasis. It also normalizes capillary permeability besides rein- forcing capillary resistance.
It is generally well tolerated, includ- ing in pregnancy, with a lower or identical rate of side effects as placebo. Mild GI symptoms such as nausea and gastric discomfort or mild auto- nomic symptoms such as headache and vertigo Safety in pregnancy and lactation: It can be used in the 2nd and 3rd trimester and during lactation.
Micronized Purified Flavonoid Fraction, MPFF]
This is an improved diosmin/hesperidin formulation in which the particles of active substance are micronized to particle sizes of less than 1.7μ in comparison to an average size of 37μ for non- micronized diosmin. This increases the rate of GI absorption of the active substance by 52% result- ing in a gain in clinical efficacy of 30% in terms of improvement of symptoms.
Drug interaction: No drug interaction has been reported during therapeutic trials. It contains no glucose and only 2mg of sodium and can there- fore be prescribed for diabetic and/or hypertensive patients, even at 6 tablets per day.