Prophylaxis and treatment of post- partum and post-abortal haemorrhage; quickening of expulsion of uterine contents in case of incom- plete abortion; diagnosis of angina pectoris by Cardiologist Specialists
1.M; inj 200-500mcg [onset of action 5-7 minutes. Duration of action is 45 minutes]. 1.V inj 100-500mcg [onset of action is one minute]
Mode of action
Brands containing this Ingredient
0.5 mg / mL: Amp
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Mode of Action
An ergot alkaloid with a short duration of action. It directly stimulates the uterine muscle to increase force and frequency of contractions. These contractions of the uterine wall around bleeding vessels at the placental site produce haemostasis. It also induces cervical contractions. Besides, it produces arterial vaso- constriction by stimulation of α-adrenergic, serotonin receptors and inhibition of endothelial- derived relaxation factor release.
Pregnancy; hypersensitivity to the drug
Drug interactions: Peripheral vasoconstriction is potentiated by the general anesthetics; vasoconstrictors; nicotine absorption from heavy smoking may result in enhanced vasoconstriction