Treatment of advanced oestrogen receptor positive breast cancer in women with natural or induced postmenopausal status whose disease has progressed following antioestrogen such as tamoxifen therapy
Adults and elderly patients: 25 mg OD
Not recommended for use in children.
Mode of action
Brands containing this Ingredient
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Mode of Action
An irreversible, steroidal aromatase inhibitor that inhibit conversion of androgens into oestrogens through the aromatase enzyme in peripheral tissues
Due to its mode of action, it should not be administered to pre-menopausal women. It should not be co-administered with oestrogen-containing medicines as these would negate its pharmacological action.
Pts with a known hypersensitivity to exemestane or to any of the excipients
The most frequent common adverse events were hot flushes, nausea, fatigue, in-creased sweating and dizziness. Other less common adverse events include headache, insomnia, pain, skin rash, abdominal pain, anorexia, vomiting, depression, alopecia, peripheral or leg oedema, constipation, dyspepsia, lymphopenia