Reversal of benzodiazepine sedative effects. Patients may be re-sedated after its administration because the drug has a short-half life - peak effect occurring at 6 to 10 minutes [shorter than midazolam and diazepam]; benzodiazepine overdose; hepatic encephalopathy
I.V inj, 200mcg over 15secs, followed by 100mcg at 60 secs interval when necessary. Usual dose range 300-600mcg [max 1-2mg] I.V infusion, 100-400 mcg/hr, in case drowsiness occurs after injection.
Mode of action
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Mode of Action
Competitive antagonist at benzodiazepine receptors.
Epileptics on prolonged benzodiazepine therapy. Concomitant use with proconvulsant drugs such as theophylline and antihistamines
Flushing; nausea and vomiting; transient blood pressure and heart rate increase; fear and anxiety at times due to too rapid awakening; seizures.
It is a 1, 4-imidazobenzodiazepine derivative. It is structurally related to benzodiazepine agonists.