Carcinoma of colon, rectum, breast, stomach and pancrease in inoperable patients; topical treatment of multiple actinic or solar keratoses
12mg/kg I.V once daily for 4 successive days [max. daily dose is 800mg].
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Its deoxyribonucleotide metabolite, 5-fluoro-2'-deoxyuridine-5'-phosphate, inhibits thymidylate synthetase. This leads to inhibition of methylation of deoxyuridylic acid to thymidylic acid hence interfering with the formation of DNA. Some fluorouracil molecules are also incorporated into RNA to form fraudulent RNA strands. Fluorouracil is also known to inhibit utilization of preformed uracil in RNA synthesis by blocking uracil phosphatase.
Only physicians experienced in cancer chemotherapy should use it; increased incidence of infections; to hospitalize the patients during the initial stages of treatment.
Leukopenia; stomatitis; esophago-pharyngitis; diarrhea; thrombophlebitis; anorexia; nausea and vomiting; alopecia; allergic reactions; pancytopenia; thrombocytopenia; agranulocytosis; anemia; acute cerebellar syndrome; GI ulceration; GI bleeding; myocardial ischemia; angina; euphoria; epistaxis; nail changes; lacrimal duct stenosis; visual changes; lacrimation.
Drug interactions: Leucovorin calcium [enhanced toxicity of fluorouracil]