Prostate Cancer: Adults-250mg TID. Stage B2-C Prostatic Carcinoma: Adults-Start treat-ment at 8 weeks prior to initiating radiation therapy and continue during radiation therapy. Stage D2 Metastatic Carcinoma: Adults: Initiate flutamide capsules with the LHRH agonist and continue until progression.
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It competes with testosterone and its metabolite, dihydrotestosterone for binding to androgen receptors in the prostate gland. By doing so, it prevents them from stimulating the prostate cancer cells to grow. [It is a substituted anilide]
Patients with severe hepatic impairment
Gynaecomastia; GI disturbances; hepatic damage; allergic reactions; hot flushes; loss of libido