An alternative for penicillin-allergic patients; intestinal amoebiasis, chlamydial, mycoplasmal infections, URTI, LRTI, skin and soft tissue infections, gonococcal male urethritis and female pelvic infections, long term prophylaxis of rheumatic fever, early syphillis in penicillin allergic patients, tetanus, legionnaires disease.
0.9–1.8g daily in 2-3 divided doses. Children: 35-50mg/kg/day in divided doses.
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Binds to 50s sub-unit of the bacterial ribosome and inhibits bacterial protein synthesis by preventing attachment of aminoacyl transfer RNA to its acceptor site on the ribosome. This prevents peptide bond formation by peptidyl transferase.
Lactation, impaired hepatic func- tions. Do not give together with chloramphenicol, pregnancy especially first trimester, monitor prothrombin times during coumarin-type anti- coagulant concommitant therapy.
Allergy to the drug or any other component of the product.
Pseudomembranous colitis, GI disturbances, allergic reactions, reversible hearing loss, super-infections, ventricular arrythmias with prolonged QT interval, agranulocytosis, myasthe- nia-like syndrome, pancreatitis, Stevens-Johnson and toxic epidermal necrolysis, hepatic dysfunc- tions, fever.
It shows greater in vitro potency than erythromycin against Legionella pneumophila, Mycoplasma hominis, Ureaplasma urealyticum and erythromycin-resistant staphylococcal and streptococcal species. It however possesses poor overall activity against Haemophilus influenzae and Enterobacteriaceae