Adults: Initially up to 75mg for outpatients. For hospitalized patients the dose is increased stepwise to 150mg-200mg. Maintenance dose: 150-200mg daily.
Mode of action
Brands containing this Ingredient
Imipramine, by Metro
Drug Index 2.0 is hereOur new update features a more powerful search feature and easier login.
issues? Contact us
today. Contact Us
Mode of Action
The mechanism of action of is not fully known but may be due to its increasing the synaptic concentration of norepinephrine and/or serotonin in the central nervous system [CNS]. These neurotransmitters are thought to be increased through inhibition of their reuptake by the presynaptic neuronal membrane.
Blood monitoring; history of epi- lepsy; pregnancy and lactation; history of mania; close angle glaucoma; concurrent electroconvul- sive therapy; anaesthesia; elderly; hepatic impairment; psychosis; withdraw gradually.
Severe hepatic disorders; acute recovery phase following myocardial infarction; hypersensitivity to tricyclic drugs; MAOIs.
Antimuscarinic actions namely: drowsiness; urinary retention; dry mouth; constipation; blurred vision; sweating; hypotensive effect, which may lead to dizziness and syncope. Arrhythmias and heart block; convulsions; haematological and hepatic reactions