Infections caused by chlamydia (trachoma, psittacosis, salpingitis, urethritis, and lymphogranuloma venereum), rickettsia (including Q-fever), brucella (doxycycline with either streptomycin or rifampicin), and the spirochaete, Borrelia burgdorferi (Lyme disease). Respiratory and genital mycoplasma infections, in acne, destructive (refractory) periodontal disease, exacerbations of chronic bronchitis (because of their activity against Haemophilus influenzae), and for leptospirosis in penicillin hypersensitivity (as an alternative to erythromycin). Prophylaxis of malaria due to Plasmodium falciparum in short term travelers (4 months) to areas with chloroquine and/or pyrimethamine-sulphadoxine resistant strains.
Adult dose: Orally, 200 mg daily in divided
doses, every 12 hours; an initial loading dose of
200mg may be given.
An oral dose of 50mg twice daily or 100mg once
daily is used for the treatment of acne; alterna-
tively, a dose of about 1mg/kg once daily is also
given as a modified-release preparation to pa-
tients weighing 45kg and over. In asymptomatic
meningococcal carriers, 100mg has been given
orally twice daily for 5 days, usually followed by
a course of rifampicin.
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Inhibits protein synthesis of susceptible bacteria hence preventing cell replica- tion. It has bacteriostatic properties.
Renal and hepatic impairment, increased risk of nephrotoxicity if given with potent nephrotoxic drug. May aggravate myasthenia gravis symptoms.Increased risk of lupus-erythematosus-like syndrome and sometimes causes irreversible pigmentation.
Pregnancy and lactation, children under 12 years, SLE, co-administration with hepatotoxic drugs.
GI disturbances, super-infections, tooth discolouration and interference with bone development in children below 12 years. Renal and hepatic disturbances, photosensitivity, negative nitrogen balance in elderly, increase intra-ocular pressure, Jarisch-Herxheimer-like reaction, nail discolouration.