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Infections caused by chlamydia (trachoma, psittacosis, salpingitis, urethritis, and lymphogranuloma venereum), rickettsia (including Q-fever), brucella (doxycycline with either streptomycin or rifampicin), and the spirochaete, Borrelia burgdorferi (Lyme disease). Respiratory and genital mycoplasma infections, in acne, destructive (refractory) periodontal disease, exacerbations of chronic bronchitis (because of their activity against Haemophilus influenzae), and for leptospirosis in penicillin hypersensitivity (as an alternative to erythromycin). Prophylaxis of malaria due to Plasmodium falciparum in short term travelers (4 months) to areas with chloroquine and/or pyrimethamine-sulphadoxine resistant strains.
Adult dose: Orally, 200 mg daily in divided doses, every 12 hours; an initial loading dose of 200mg may be given. An oral dose of 50mg twice daily or 100mg once daily is used for the treatment of acne; alterna- tively, a dose of about 1mg/kg once daily is also given as a modified-release preparation to pa- tients weighing 45kg and over. In asymptomatic meningococcal carriers, 100mg has been given orally twice daily for 5 days, usually followed by a course of rifampicin.
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