All forms of Parkinsonism except drug induced Parkinsonism
(Expressed as L-dopa). Initially 100-125mg 3-4 times daily (to 0.75-1.5g daily in divided doses).
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Levodopa is an amino acid precursor of dopamine, which acts mainly by replenishing depleted striatal dopamine. Carbidopa is an extracerebral dopa decarboxylase inhibitor, which prevents the peripheral degradation of levodopa to dopamine. It does not cross the blood-brain barrier hence higher concentrations of dopamine are attained in the brain.
Monitor hepatic, renal, haematological and cardiac functions, discontinue 2-3 days before surgery, stomach ulcers, monitor intraocular pressure, osteomalacia.