Local anaesthesia; parenterally for the acute treatment of ventricular arrhythmias occurring after myocardial infarction or during cardiac procedures such as cardiac surgery or cardiac catheterization; drug of choice for the treatment of ventricular premature contractions [VPCs] associated with myocardial infarction; status epilepticus as a last resort.
Local Anaesthesia: use the lowest dose needed to provide effective anaesthesia.Adults: the dose not greater than 200 mg. For spinal anaesthesia not greater than 100 mg. Children:the dose not more than 3mg/kg. Use in Cardiac Arrhythmias -Adults: 50 -100 mg IV at a rate of about 25-50 mg per minute. No more than 200 - 300 mg within 1 hr
Mode of action
Brands containing this Ingredient
inj., with adrenaline
with adrenaline inj
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Mode of Action
It acts by stabilizing the membranes of the nerve cells by decreasing their permeability to sodium ions.
ECG monitoring is necessary during its IV administration; liver disease, con- gestive heart failure, marked hypoxia, severe respiratory depression, hypovolemia, or shock; administering lidocaine to patients with sinus bradycardia or incomplete heart block for the treatment of ventricular premature contractions without prior acceleration of heart rate; fibrillation.
Known hypersensitivity to the amide-type local anesthetics; patients with Adams-Stokes syndrome or with severe degrees of SA, AV, or intraventricular heart block in the absence of an artificial pacemaker.
Serious side effects are uncommon. Drowsiness; dizziness; disorientation; confusion; lightheadedness; psychosis; apprehension; tinni- tus; visual disturbances including amblyopia or diplopia; nausea; vomiting; paraesthesia; sensa- tions of heat, cold, or numbness; difficulty swal- lowing; dyspnea; and slurred speech; muscle twitching or tremors, seizures, unconsciousness, coma, and respiratory depression; hypersensitivi- ty reaction; hypotension, arrhythmias, heart block; local thrombophlebitis.
Drug interactions: Succinylcholine [effect poten- tiated by lignocaine]; antiarrhythmic drugs [cardiac effects may be additive or antagonistic and toxic effects may be additive]; cimetidine and propranolol substantially reduce the systemic clearance of lidocaine.
Use of lidocaine with adrenaline prolongs its duration of action and prevents its widespread to non-required areas.